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Chemical Products Candesartan Material and Products

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CAS No:139481-59-7
Synonyms:2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid;2-ETHOXY-1-[[2′-(1H-TETRAZOL-5-YL)(1,1′-BIPHENYL)-4-YL]METHYL]-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID;CANDESARTAN;CV-11974;CILEXITIL;Candesartan[CandesartanCilexetilIntermediates];Can

Chemical Products Candesartan Description
Crystalline SolidChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension.Candesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic

Chemical Products Candesartan Basic Attributes
CAS No:139481-59-7

Molecular Formula :C24H20N6O3

Molecular Mass :440.45

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Exact Mass :440.159698

PSA :119 A^2

LogP :4.1

EINECS :1806241-263-5


H-bond Acceptor :7

H-bond Donor :2

SP3 :0.13

RBN :7

Chemical Products Candesartan Characteristics
Density :1.41±0.1 g/cm3(Predicted)

Melting Point :183-185°C

Bolling Point :754.8±70.0 °C(Predicted)

Flash Point :410.3±35.7 °C

Refractive Index :1.719

Solubility :soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).

Storage Condition :-20°C Freezer

Vapor Pressure :1.8X10-18 mm Hg at 25 deg C (est)

Stability :Stable under recommended storage conditions.

Chemical Products Candesartan Safety Information
HS Code :29419000

UN No. :NONH for all modes of transport

Risk Code :20/21/22-36/37/38

Safety Instructions :26-36-60-36/37-9

RTECS No. :DD6671000

Dangerous Mark :Xn

P Code :P201, P202, P261, P271, P281, P304+P312, P304+P340, P308+P313, P312, P405, P501

Hazard Statements :H332

Chemical Products Candesartan Product Usage
antihypertensive, angiotensin II inhibitor

Chemical Products Candesartan Production Methods
To the product obtained in Step A) (350 g) dissolved in methanol (1.17 L) was added sodium hydroxide solution (93 g in 1.17 L water). The reaction mass was heated to reflux at 78-80°C and maintained for 1 hour. After completion of reaction, methanol was completely removed under vacuum at 40-45°C and to the residue was added ethyl acetate (2. 8 L) and water (3.50 L) at room temperature. Stirred the mixture for about 1 hour at 25- 30°C and allowed to settle for 15 minutes. Separated the layers and pH of the aqueous layer was adjusted to 4-5 with acetic acid (about 450 g) at 10-15°C. The precipitated product was filtered and washed twice with water (2 x 0.7 L) and suck dried. The wet cake was air dried at room temperature for 2 hours and then at 50-55°C to afford the title compound.

Chemical Products Candesartan Material and Products
Material :
Sodium Azide, 3-Nitrophthalic acid, Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl], Thionyl chloride, Mineral Oil, BENZOIC ACID, 2-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-3-NITRO-METHYL ESTER, Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-y…, Mineral Oil, Potassium Carbonate, Azilsartan pharMaceutical interMediate, tert-Butylalcohol, 1-Methyl-3-nitrophthalate, BENZOIC ACID, 2-[[(2′-CYANO[1,1′-BIPHE…, Trifluoroacetic Acid

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