CAS No:139481-59-7
Formula:C24H20N6O3
Synonyms:2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid;2-ETHOXY-1-[[2′-(1H-TETRAZOL-5-YL)(1,1′-BIPHENYL)-4-YL]METHYL]-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID;CANDESARTAN;CV-11974;CILEXITIL;Candesartan[CandesartanCilexetilIntermediates];Can
Chemical Products Candesartan Description
Crystalline SolidChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension.Candesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic
Chemical Products Candesartan Basic Attributes
CAS No：139481-59-7
Molecular Formula ：C24H20N6O3
Molecular Mass ：440.45
Exact Mass ：440.159698
PSA ：119 A^2
LogP ：4.1
EINECS ：1806241-263-5
InChIKeys ：HTQMVQVXFRQIKW-UHFFFAOYSA-N
H-bond Acceptor ：7
H-bond Donor ：2
SP3 ：0.13
RBN ：7
Chemical Products Candesartan Characteristics
Density ：1.41±0.1 g/cm3(Predicted)
Melting Point ：183-185°C
Bolling Point ：754.8±70.0 °C(Predicted)
Flash Point ：410.3±35.7 °C
Refractive Index ：1.719
Solubility ：soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
Storage Condition ：-20°C Freezer
Vapor Pressure ：1.8X10-18 mm Hg at 25 deg C (est)
Stability ：Stable under recommended storage conditions.
Chemical Products Candesartan Safety Information
HS Code ：29419000
UN No. ：NONH for all modes of transport
Risk Code ：20/21/22-36/37/38
Safety Instructions ：26-36-60-36/37-9
RTECS No. ：DD6671000
Dangerous Mark ：Xn
P Code ：P201, P202, P261, P271, P281, P304+P312, P304+P340, P308+P313, P312, P405, P501
Hazard Statements ：H332
Chemical Products Candesartan Product Usage
antihypertensive, angiotensin II inhibitor
Chemical Products Candesartan Production Methods
To the product obtained in Step A) (350 g) dissolved in methanol (1.17 L) was added sodium hydroxide solution (93 g in 1.17 L water). The reaction mass was heated to reflux at 78-80°C and maintained for 1 hour. After completion of reaction, methanol was completely removed under vacuum at 40-45°C and to the residue was added ethyl acetate (2. 8 L) and water (3.50 L) at room temperature. Stirred the mixture for about 1 hour at 25- 30°C and allowed to settle for 15 minutes. Separated the layers and pH of the aqueous layer was adjusted to 4-5 with acetic acid (about 450 g) at 10-15°C. The precipitated product was filtered and washed twice with water (2 x 0.7 L) and suck dried. The wet cake was air dried at room temperature for 2 hours and then at 50-55°C to afford the title compound.
Chemical Products Candesartan Material and Products
Material ：
Sodium Azide, 3-Nitrophthalic acid, Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl], Thionyl chloride, Mineral Oil, BENZOIC ACID, 2-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-3-NITRO-METHYL ESTER, Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-y…, Mineral Oil, Potassium Carbonate, Azilsartan pharMaceutical interMediate, tert-Butylalcohol, 1-Methyl-3-nitrophthalate, BENZOIC ACID, 2-[[(2′-CYANO[1,1′-BIPHE…, Trifluoroacetic Acid
